Mexico continues to be a popular destination for those who want a taste of Latin America. While there’s plenty of resorts and beach-side cities to visit, we’re big fans of Guadalajara, the country’s second-largest city. Over the last few years, Guadalajara has exploded in popularity, and rightfully so, as there’s plenty to do there, from sightseeing to eating and drinking.
Choosing where to stay in Guadalajara can make or break your trip. Pick the wrong neighborhood and you’ll spend hours sitting in traffic trying to reach the actually good, non-touristy restaurants and landmarks. For first timers, two neighborhoods consistently deliver the best mix of safety, walkability, and authentic Mexican culture.
Colonia Americana Is Perfect For Nightlife and Walkability
Colonia Americana is the trendiest neighborhood in Guadalajara, and for good reason. The main street, Avenida Chapultepec, is lined with hip coffee shops, rooftop bars, trendy restaurants, and late night taco stands where locals actually hang out. There’s also a small community of digital nomads who have made the area their home, giving it a fresh, new vibe.
One could argue that this is the most walkable neighborhood in the city. Everything is flat, the streets feel safe during the day, and you can stroll to museums, galleries, and parks without needing a car. One of the best museums you can visit in the area is Museum of Arts, University of Guadalajara, which continues to have some of the coolest, evocative art in the entire city (and country).
The area attracts young professionals, digital nomads, and travelers who want that vibrant energy without being stuck in a sterile hotel zone. If you want nightlife, this is your best bet. And if you’re traveling for the upcoming FIFA matches, be sure to book your hotels in the area early, as Colonia Americana is going to be the place to be during soccer season!
Tlaquepaque For Colonial Charm and Mariachi
If Colonia Americana feels too modern and you want that postcard perfect and rustic Mexican experience, Tlaquepaque delivers cobblestone streets, colonial architecture, and live mariachi music playing at El Parián square every afternoon and evening. It’s nothing short of infectious, and the area is worth visiting even if you’re not staying/sleeping there.
A note though: Tlaquepaque is technically its own city just southeast of Guadalajara, but it’s a quick metro ride to the main attractions. The neighborhood is famous for artisan pottery, blown glass, and handicrafts, with working studios you can visit. The pedestrian street Calle Independencia is packed with boutiques and restaurants serving gourmet Mexican food in hacienda style settings. If you’re looking for something a bit more low-key, less hectic, and don’t mind a small commute to the main destinations, Tlaquepaque is totally the place to be. Plus, it’ll be a bit cheaper to stay here, which is always a bonus.
